Endocrine Abstracts

Hyperinsulinism has been shown to trigger sympathetic activity experimentally, however the clinical and epidemiologic data on the association of heart rate with hyperinsulinism and insulin resistance. This study was investigated the relationship between insulin resistance and exercise test parameters in unselected consecutive middle aged asymptomatic patients with type II diabetes.Ninety asymptomatic type II diabetics between the ages 36 and 60 without a...

Hydrocortisone reveals its action by activation of transcription of specific genes that is achieved by binding of hormones nuclear receptors (NRs) to cognate sites on DNA and recruiting coactivators of basal transcription machinery. NRs are able to overcome restricting conformation of chromatin by altering chromatin-remodeling machinery (chromatin-remodeling protein complexes, histone and nonhistone modifying enzymes). However, a possibility arise that genomic DNA accessibilit...

Orexins, in addition to regulating food intake and playing a role in the sleep wake cycle, are involved in the activation of HPA axis. Starvation induces metabolic changes in the body, including upregulation of orexin and its receptors in the hypothalamus. We investigated the expression and signalling characteristics of rat orexin receptors at the hypothalamic and adrenal level in food deprived animals and controls. Food deprivation induced both orexin type-1 (OX1R) and type-2...

Klinefelter syndrome is an abnormality of sexual development which is usually characterised by the chromosome complement of 47,XXY, although occasionally patients may have multiple X or Y chromosomes, may be mosaic with 46, XY, 47,XXY or have an X-autosome translocation. We present the case of a 43 year old male patient with the phenotypic appearance of Klinefelter syndrome and primary infertility, who was found on karyotype analysis to have an hitherto undescribed inversion o...

A 35 year old lady presented to endocrine services with a background of attempted conception and oligomenorrhoea. Presenting features were typical of acromegaly including sweating, acne and median nerve entrapment. Growth hormone day curve showed unrelenting high levels of growth hormone. Serum IGF-1 was elevated at 154 nmol/l (normal 14.2–36.9). Other pituitary blood tests were within normal limits. A pituitary macroadenoma measuring 1.5×1.5×1.3 cm was found on...

A 20-year-old female first presented in 2013 with a six-month history of feeling faint, palpitations, weight loss and oligo-amenorrhoea. She was found to have autoimmune thyrotoxicosis with a fT3 15.2, fT4 43.3, TSH <0.05 and TPO antibodies strongly positive. She was subsequently commenced on Carbimazole 20 mg once a day and was biochemically euthyroid within 6 months. Interestingly, however, she continued to lose weight and remained oligo-amenorrhoeic. ...

A 20-year-old female first presented in 2013 with a six-month history of feeling faint, palpitations, weight loss and oligo-amenorrhoea. She was found to have autoimmune thyrotoxicosis with a fT3 15.2, fT4 43.3, TSH <0.05 and TPO antibodies strongly positive. She was subsequently commenced on Carbimazole 20 mg once a day and was biochemically euthyroid within 6 months. Interestingly, however, she continued to lose weight and remained oligo-amenorrhoeic. ...

Testosterone deficiency syndrome (TDS) may well contribute to a number of co morbidities and multitude of symptoms which may affect one’s daily activities adversely. TDS prevalence in UK is 1:500 and certain groups of patient’s are at higher risk of TDS, in particular elderly and patients with diabetes mellitus where 42% are known to have TDS. A retrospective audit was carried out to bench mark our practice in line with a publication of a recommended National/Europea...

Erosio interdigitalis blastomycetica is a special form candidiasis commonly seen in the third web space of digits, but can spread to all web spaces. Diagnosis is clinically suspected in the presence of maceration and ulceration, erythema, sometimes associated with pain. The main predisposing condition is chronic maceration (for example in launderers), irritant chronic agents and prolonged moisture affect skin barrier with subsequent colonization of Candida spp. Direct...

Case history: A 20-year-old female first presented to our endocrine clinic in 2013 with a 6-month history of feeling faint, palpitations, weight loss and oligo-amenorrhoea. She was found to have autoimmune thyrotoxicosis with a fT3 of 15.2, fT4 43.3 and TSH <0.05. Her TPO antibodies were strongly positive. She was subsequently commenced on Carbimazole 20 mg once a day and was biochemically euthyroid within 6 months. Interestingly, however, she continued to lose weight and ...